Magnesium sulfate crosses the placenta to the baby, and babies may experience side effects that include poor muscle tone and low Apgar scores. These side effects are usually gone in a day or so and don’t cause long-term problems.
What does magnesium sulfate do to babies?
Magnesium sulfate is a tocolytic, a medication used to suppress preterm labor, and can be used to help slow or inhibit contractions to delay the birth of a preterm baby. Magnesium sulfate lowers the amount of calcium in the uterine muscles which, in turn, encourages muscle relaxation.
Does magnesium affect baby?
In a baby, magnesium toxicity can cause low muscle tone. This is caused by poor muscle control and low bone density. These conditions can put a baby at greater risk for injuries, such as bone fractures, and even death.
Does magnesium sulfate cause birth defects?
Administration of magnesium sulfate injection to pregnant women longer than 5-7 days may lead to low calcium levels and bone problems in the developing baby or fetus, including thin bones, called osteopenia, and bone breaks, called fractures.
What are the signs of magnesium toxicity in the mother and the baby?
The patient should be assessed for signs of toxicity (e.g., visual changes, somnolence, flushing, muscle paralysis, loss of patellar reflexes) or pulmonary edema. If these signs are observed, a physician must be notified.
What is one of the serious side effects of magnesium sulfate?
Side effects of magnesium sulfate injection include:
- heart disturbances,
- breathing difficulties,
- poor reflexes,
- flushing (warmth, redness, or tingly feeling),
- lowered blood pressure,
What is the primary action of magnesium sulfate when given in preeclampsia?
It is also utilized for prophylactic treatment in all patients with severe preeclampsia. The mechanism of action of magnesium sulfate is thought to trigger cerebral vasodilation, thus reducing ischemia generated by cerebral vasospasm during an eclamptic event.
Why should you avoid magnesium in the last trimester?
Magnesium-containing antacids should be avoided during the last trimester of pregnancy because it could interfere with uterine contractions during labor.
Why is magnesium given during labor?
Magnesium sulfate is given as an intravenous infusion or intramuscular injection in the hospital over 12 to 48 hours. It relaxes smooth muscle tissues, which helps to prevent seizures and slow uterine contractions.
What does magnesium help with during pregnancy?
Magnesium and calcium work in combination: Magnesium relaxes muscles, while calcium stimulates muscles to contract. Research suggests that getting adequate magnesium during pregnancy can help prevent the uterus from contracting prematurely. Magnesium also helps build strong teeth and bones in your baby.
When do you stop MgSO4 in eclampsia?
– Category A : 80 patients given full dose of maintenance MgSO4 (4 grams of MgSO4 on 250 ml ringer solution over 4 hours every 4 hours by IV drip for 24 hours) in the postpartum period.
New Magnesium Sulphate Protocol for Pre-eclampsia.
|Condition or disease||Intervention/treatment||Phase|
|Pre-eclampsia||Drug: MgSO4||Phase 3|
How do you reverse magnesium sulfate toxicity?
Calcium gluconate: the antidote for magnesium toxicity is calcium gluconate 1 g IV over 3 minutes. Repeat doses may be necessary. Calcium chloride can also be used in lieu of calcium gluconate.
When does magnesium sulfate stop labor?
The administration of magnesium sulfate in women with preterm labor pain leads to inhibition of uterine contractions and delay in delivery for at least 48 hours. Administration of magnesium sulfate in the intervention group increases this period 2.7 times the same as in the control group.
What should I check before giving magnesium sulfate?
Before repeating administration of MgSO4, check that: – Respiratory rate is at least 16 per minute. – Patellar reflexes are present. – Urinary output is at least 30 mL per hour over 4 hours.
Why is magnesium sulfate considered a high risk medicine?
Magnesium sulfate is on the Institute of Safe Medication Practices (ISMP) “List of High-Alert Medications” because there is serious risk of causing significant patient harm when used in error.
What is the antidote to treat magnesium toxicity?
Intravenous calcium chloride or gluconate represent the antidotes for hypermagnesemia, and 1-2 ampules should be administered immediately if symptomatic or otherwise serious hypermagnesemia develops.