Is propranolol contraindicated in pregnancy?

Propranolol use in late pregnancy may cause the baby to have symptoms of the drug acting on its heart, blood vessels, and metabolism. Symptoms would include slowed heart rate and low blood sugar. Does taking propranolol in pregnancy cause long-term problems in behavior or learning for the baby.

Is it safe to take propranolol while pregnant?

Propranolol has been used safely to treat a variety of conditions during pregnancy, including hypertension and pheochromocytoma in the mother, and tachyarrhythmias in both the mother and fetus.

Are beta-blockers contraindicated in pregnancy?

Beta-blockers used to treat hypertension during the first trimester of pregnancy don’t appear to increase the risk that babies will be born with birth defects or cardiac malformations, according to an analysis of observational data on more than 18,000 women across five Nordic countries and the United States.

Which beta blocker is not safe in pregnancy?

Conclusions The authors found that exposure to β-blockers during pregnancy was associated with being born SGA, preterm birth and perinatal mortality. Our findings show that labetalol is not safer than other β-blockers during pregnancy.

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Are beta-blockers safe during pregnancy?

β-Blockers are the most commonly used class of medication for treating cardiac conditions in pregnant women. Despite the common use of this class of medication, data that support its safety are limited. β-Blockers cross the placenta and potentially can cause physiological changes in the fetus.

Can propranolol cause a miscarriage?

Can taking propranolol in pregnancy cause miscarriage? A single study provided no evidence that use of propranolol in early pregnancy was linked to an increased risk of miscarriage. No further studies have assessed miscarriage rates in women taking propranolol and more research into this subject is therefore required.

Can propranolol make you gain weight?

During the first few months of treatment, beta-blockers are usually linked to weight gain (about 1.2 kg on average), followed by a plateau. The amount of weight gain may only be moderate, with atenolol causing weight changes in the range of -0.5–3.4 kg; propranolol, -0.5–2.3 kg; and metoprolol, 1.2–2.0 kg.

What pregnancy category are beta blockers?

Most beta-blockers were given the former Pregnancy Letter Category C by the US Food and Drug Administration, meaning that “risk cannot be ruled out” [8] because experimental animal studies have shown an adverse effect on the foetus or there have been no adequate and well-controlled studies in humans.

Can beta blockers cause stillbirth?

In our study, an extensive data analysis showed a direct relationship between beta receptor expo- sure and pregnancy. It was confirmed that exposure to beta-blockers during pregnan- cy is associated with a higher risk of SGA (1.72 fold), stillbirth (2.59 fold), and Neonatal hypo- glycemia (2.60 fold).

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Which antihypertensive is contraindicated in pregnancy?

ACE-Is and angiotensin receptor blockers should be avoided in all trimesters; when administered in the second and third trimesters, they are associated with a characteristic fetopathy, neonatal renal failure, and death, and, thus, are contraindicated.

Will labetalol affect my baby?

Labetalol is not thought to harm an unborn baby. But there’s a small chance that when your baby’s born the medicine can affect their blood sugar levels. For this reason your baby may be monitored for the first 24 hours to make sure everything is OK.

Why diuretics are contraindicated in pregnancy?

Diuretics given after the first trimester interfere with normal plasma volume expansion, which may exacerbate the volume depletion in pre-eclampsia and cause intrauterine growth retardation [3]. Diuretics have not been reported to have teratogenic effects.

Why ACE inhibitors are contraindicated in pregnancy?

It is well accepted that angiotensin-converting enzyme (ACE) inhibitors are contraindicated during the second and third trimesters of pregnancy because of increased risk of fetal renal damage.

Do beta blockers decrease milk supply?

In general, beta blockers that are considered to pose less risk to a breastfeeding infant have, or are predicted to have, lower levels in breast milk (due to a high degree plasma protein binding, low lipid solubility and a short half-life) and relatively low renal excretion.

Are Beta Blockers Safe?

Beta blockers are generally safe to take. Side effects tend to be annoying, not life-threatening.

What are natural beta blockers?

8 Natural Sources Of Beta-blockers To Treat Hypertension

  • Anti-oxidant fruits and vegetables. Anti-oxidants help prevent inflammatory conditions and lower blood pressure. …
  • Pulses. …
  • Leafy green vegetables. …
  • Garlic. …
  • Saffron. …
  • Low-fat dairy products. …
  • Bananas. …
  • Fish.
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